Role of Magnetic Field in Parkinsons Disease

Role of Magnetic Field in Parkinsons Disease Role of Magnetic Field in Diagnosis and Treatment of Parkinson’s Disease Jehan Zaib Ali Khan, M.Phil. Abstract: Parkinson’s disease (PD) is a neurological disease. It is due to less production of Dopamine in brain. There is no permanent treatment of this disease. But with the passage of time some useful techniques and medicines are developed for diagnosis and treatment, to overcome its signs. MRI and TMS are also included in these techniques. Magnetic Field is basic thing in these techniques. Role of magnetic field is very useful to diagnose and to cure this disease but there is need of further research and work to make these techniques more effective and safe. I have studied and reviewed different researches about these techniques and try to summarize the role of magnetic field in this article. Keywords: magnetic field (MF), magnetic resonance imaging (MRI), transcranial magnetic simulation (TMS), parkinson’s disease (PD), deep brain simulation (DBS), repeated transcranial magnetic simulation (rTMS) Introduction: Parkinson’s disease is a neurological disorder. It is very chronic disease. Patients with this disease have great difficulty in movement. They also face non-motor complications like loss of appetite, sleep deprivation and pain. There is no permanent solution of this disorder. But with the passage of time some techniques and medicines are developed for proper diagnosis and treatment to overcome its symptoms. Levodopa is a basic medicine to fulfill the requirement of dopamine because lack of dopamine in brain is the basic cause of this disease. But there are some side effects of Levodopa. Levodopa-induced dyskinesias are a common complication of chronic dopaminergic therapy in patients with Parkinsons disease (PD). The overall prevalence of levodopa-induced dyskinesias ranges from 40%-90% and is related to the underlying disease process, pharmacologic factors, and to the duration of high dose levodopa therapy.[1] In that case another method is necessary to cure PD and overcome d yskinesias. For this purpose artificial week magnetic fields can be used that have dramatic effect.[1] For diagnosis purpose magnetic resonance imaging (MRI) is very useful. Another step in this direction is functional MRI which describes the neural mechanism of movement automaticity in PD patient.[2] Magnetic Field and Diagnosis of PD: MRI uses strong magnetic field, radio waves and computers to produce detailed images of interior of body. It gives 3-D image representation of internal parts of body. In this way, it is very useful for diagnosis of PD. MRI scanner contains powerful magnets. A strong magnetic field is created by passing an electric current through the wire loops. During this process, other coils in the magnet send and receive radio waves. This triggers protons in the body to align themselves. Once aligned, radio waves are absorbed by the protons, which stimulate spinning. Energy is released after exciting the molecules, which in turn emits energy signals that are picked up by the coil. This information is then sent to a computer which processes all the signals and generates it into an image.[3] Functional MRI is advance form of MRI. It can be used to investigate the underlying neural mechanisms of movement automaticity in Parkinson’s disease patients.[2] Deep brain stimulation (DBS) has become an efficient instrument in the symptomatic therapy of PD. Functional MRI can be used safely for this purpose. Positron emission tomography (PET) is used quite widely in studies dealing with DBS and with PD. fMRI has never used for this purpose but safety of fMRI during thalamic DBS has been proven by a study with a heterogeneous group of patients suffering from neurological disorders.[4] Single pulse transcranial magnetic simulation (TMS) can be used for investigation and diagnosis.[5] Magnetic Field and Treatment of PD: In 1992, it was reported that reported that extracranial treatment with picotesla range magnetic fields is an effective, safe, and revolutionary modality in the management of Parkinsonism. Also for those patients, whom are facing levodopa-induced motor complications. [6][7] It also produces improvements in non-motor aspects like sleep, appetite, pain, mood and sexual behavior. A comprehensive study on a PD patient shows that magnetic field in the range of picotesla is very useful as antiparkinsonian. In this way it reduces the requirement of antiparkinsonian medicines like levodopa.[7] In 2008, Therapeutic effects of low-frequency repetitive transcranial magnetic stimulation (rTMS) were investigated by Toshiaki FURUKAWA and others in PD with cognitive dysfunction known as impaired set switching. They apply rTMS on six patients and monitor these patients by using different tests. They applied 0.2-Hz rTMS over the frontal region at an intensity of 1.2 x. They concluded that when combined with drug therapy and rehabilitation, rTMS appears to be useful for maintaining and improving function.[8] TMS basis on principle of inductance to get electrical energy across the scalp and skull without the pain of direct percutaneous electrical stimulation. It involves placing a small coil of wire on the scalp and passing a powerful and rapidly changing current through it. This produces a magnetic field that passes unimpeded and relatively painlessly through the tissues of the head. Magnetic field induces week electrical current and to produce enough current to excite neurons in the brain, the current passed through the coil must change within a few hundred microseconds.[5] Transcranial magnetic simulation is very useful for treatment of this neurological disease but it is not permanent solution. A patient suffering from PD needs this therapy on regular basis. Sometimes medicines are also required besides of this therapy. Therefore there is need of further research and investigation to improve that treatment of PD.[8] Although single pulse TMS is very useful for investigation purposes and rTMS is very useful for treatment but rTMS may be harmful for by kindling effects as well as the past history of possible misuse of electroconvulsive therapy. It can produce adverse effects on human body like headache, effects on hearing, kindling and effects on hormones. Metallic hardware near the coil can be moved or heated by TMS, presence of metal may be harmful.[5][9] Therefore it needs to take some safety measures to control harmful effects of magnetic field. There should use simulation parameters in safe range like duration of rTMS, frequencies and intensities.[5] Future of MF in Diagnosis and Treatment of PD: Magnetic field is very useful for treatment of diagnosis and treatment of PD. But there is need of further improvement of techniques based on the use of magnetic field. These techniques can become most suitable for patients of PD reducing harmful effects of MF. In the future, the long-term therapeutic effects of rTMS, particularly with regard to the frequency, stimulation intensity and rTMS coil-type, need to be investigated Further developments related to the application of rTMS in Parkinson’s disease are expected.[8] Conclusion: Parkinson’s disease is chronic disorder. There are different medicines and techniques for its diagnosis and treatment. For this purpose use of magnetic field and its effects are very valuable. By using appropriate amount of MF one can overcome the symptoms of PD. There are some side effects of its use for diagnosis and treatment. But these side effects can be controlled by taking some necessary steps. It will not be wrong, if I say that by further research and investigation MF can become a good replacement of antiparkinson medicines. References: [1]D. K. Sandyk R , Anninos PA, Tsagas N, â€Å"Magnetic fields in the treatment of Parkinson ’ s disease . PubMed Commons,† vol. 63, p. 1342026. [2]T. Wu and M. Hallett, â€Å"A functional MRI study of automatic movements in patients with Parkinson’s disease,† Brain, vol. 128, pp. 2250–2259, 2005. [3]T. M. Deserno, Biological and Medical Physics, Biomedical Engineering. Springer, 2010. [4]R. Jech, D. Urgosà ­k, J. Tintera, a Nebuzelskà ½, J. Krà ¡senskà ½, R. Liscà ¡k, J. Roth, and E. RÃ…Â ¯zicka, â€Å"Functional magnetic resonance imaging during deep brain stimulation: a pilot study in four patients with Parkinson’s disease.,† Mov. Disord., vol. 16, no. 4, pp. 1126–32, 2001. [5]E. M. Wassermann and E. M. Wassermann, â€Å"Risk and safety of repetitive transcranial magnetic stimulation,† Electroencephalogr. Clin. Neurophysiol., vol. 108, pp. 1–16, 1998. [6]â€Å"Pulsed electromagnetic fields potentiate neurite outgrowth in the dopaminergic MN9D cell line . PubMed Commons,† vol. 92, no. 6, p. 24523147. [7]R. Sandyk, â€Å"Treatment of Parkinson’s disease with magnetic fields reduces the requirement for antiparkinsonian medications.,† Int. J. Neurosci., vol. 74, pp. 191–201. [8]T. Furukawa, S. Izumi, M. Toyokura, and Y. Masakado, â€Å"Effects of Low-frequency Repetitive Transcranial Magnetic Stimulation in Parkinson ’ s Disease,† vol. 34, no. 3, pp. 63–71, 2009. [9]P. M. Rossini, P. M. Rossini, S. Rossi, and S. Rossi, â€Å"Transcranial magnetic stimulation: diagnostic, therapeutic, and research potential,† Neurology, vol. 68, p. 484, 2007.

A Career in Sports Management Essay -- Career Research

Choosing a career is one of the most important decisions a person will make in their life. Most people try to pick the career with the best financial gain and something they would like to do for the rest of their life. Foremost it is wise to see what the job entails. Sport Management is perfect for those who enjoy helping and working with people, especially when dealing with sports. The next part of the decision-making process is looking through the various schooling and training required. Lastly, take into consideration the advantages and disadvantages. Usually with great salaries comes a big responsibility with high stress. â€Å"The sports industry in the U.S. is a $200-billion-dollar-plus powerhouse, with superstar athletes, lucrative endorsement deals, and all the free press an ego can handle† (Lawyue 1). The profession of a sport management professional has a very specific work description, requires specific schooling and training, and comes with a variety of benefits and disadvantages. As time progresses, watching and supporting sports is becoming more and more popular as a main source of entertainment. Many people have found ways to connect their jobs with their passion of sports. â€Å"The multibillion-dollar sports industry offers employment opportunities for management, marketing, and supervisory professionals at all levels of competition† (Sports Management 1). Depending on a person’s interests, there are jobs in professional, amateur, and even school sports. Once a person decides on a sport management career, it needs to be determined which area he or she more specifically wants to go into based on his or her interests and abilities. There is a wide range of groups who employ sport management pr... ...rks Cited Lawyue, Mathew. How to Pick a Sport Management Program. Undergraduate News. Bloomberg Businessweek. 18 Aug. 2012. Web. 18 Sep. 2014. â€Å"Major: Sports Management.† Princetonreview.com. The Princeton Review, n.d. Web. 4 Oct. 2014. â€Å"Manager.† Encyclopedia Britannica. Encyclopedia manager> Paulson, Edward. The Complete Idiots Guide to Starting Your Own Business. Indianapolis: Alpha Books, 2000. Print â€Å"Professional Sport.† Education-portal.com. MGMT Professions., n.d. Web. 4 Oct. 2014 â€Å"Sport Management.† Library.semo.edu. Kent Library Research Guide, n.d. Web. 18 Sep. 2014. â€Å"Sports Management.† Careers.stateuniversity.com. n.p., n.d. Web. 4 Oct. 2014 â€Å"What is Sport Management.† Winthrope.edu. Winthrope, n.d. Web. 15 Sep. 2014.

Integrative Therapy Essay

I started my first class of counselling today. I was very nervous and excited at the same time. I was nervous because I had not been in formal education for the past ten years and excited because I was going to do something for myself after 3 years of sitting at home and focus on something other than domestic issues. I arrived to my first class late and that made me more apprehensive. Looking around I noticed that there were people from different age and background. I started the class by telling others about myself and listened to them. I felt like I was in a group therapy, in a way it actually was because we were using our listening skills, which I believe is essential part of counselling. As it happened at the end of the task I was less nervous than I was at the beginning. Our next task was to find a partner and talk about ourselves to each other. We talked about our lives and it was up to us how much to tell our partner and to share it with the rest of the group. Again here, our listening skills were tested. This task also acted as ice breaker where the atmosphere of the class become more relaxed as we listened to each individual’s life and their achievements as well as their aspirations. I realised that most of the people who attended the course were there because of their life experiences propelled them to this course and that they felt they have something to give back as counsellor, or that they may learn some counselling skills to help them with their own lives. As for myself, since studying counselling as part of my degree course 10 years ago, I have wanted to become a counsellor. I always was motivated to help others. My only inability is and has been my lack of confidence. This is not because I don’t have the ability to listen and help others, but just that I am not a confident speaker and my communication skills needs to be enhanced and by doing this course I am hoping to overcome both and be prepared for further qualifications in counselling. During the class in groups we also discussed, what we want from rest of the group and what is required of me. There were some points, such as, Respect, Confidentially, Honesty, Being non- judgmental, etc, that we all agreed on. We ended the class by â€Å"checking out†, where we said how we felt and what we learned, like me, the rest of group was also more relaxed and were looking forward to the rest of the course. I see this course as learning route, where by the end of it I have learned some counselling skills, hopefully I will also overcome my own issues, which might have an impact on my role as a helper.

Word Choice Cent, Scent or Sent

Word Choice Cent, Scent or Sent Word Choice: Cent, Scent or Sent? It can be tricky to know which word to use, especially when using homophones (words that sound the same as one another). Understandably, some people mix up the words cent, scent and sent. Today, we explain what each one means and when you should use them. Cent (A Penny) The word cent is pronounced with a soft c that sounds like an s. It comes from the Latin word centum, meaning one hundred. It first started being used as a noun for currency in 1786. Since then, it has always referred to a coin worth one hundredth of a dollar: I’m really struggling for money. I’m down to my last cent. Scent (A Smell) The c in this word is silent. It comes from the Latin sentire, meaning sense. It is a noun meaning odor and is almost always applied to pleasant smells, such as perfume or flowers: The roses had such a lovely scent that she fell in love at once. Scent can also be used as a verb, especially when referring to an animals sense of smell. For example: The shark scented the blood in the water. Sent (Dispatched) Sent is the past tense of the verb send, which means dispatch. This word comes from the Old English sendam, which means send forth, throw or impel: I sent my Great-Aunt a chocolate cake through the mail. Cent, Scent or Sent? Hopefully this has cleared up the meanings of these terms a bit! Remember: Cent is a term for currency (one hundredth of a dollar) Scent  is to do with smells and the sense of smell Sent is the past tense of send and means dispatched Happy writing!

Why we should not allow performance-enhancing drugs in sports Essays

Why we should not allow performance-enhancing drugs in sports Essays Why we should not allow performance-enhancing drugs in sports Essay Why we should not allow performance-enhancing drugs in sports Essay Performance enhancing drugs considerably influence sports and athletes. Players have to pay heavy price for their life when involved in using performance enhancing drugs. Though drugs improve athlete’s performances like sports technology and equipment but its practice is not rewarded by athlete fans. It is a universal outlook of populace that players must reflect their natural talent to give superior performance which is admired with great fervor. But some advocates and athletes oppose this statement and argue for significance of performance drugs in sports. The main issue in today’s sport is that on what grounds, these drugs are banned that can help them to get more out of their training and practice. Some challengers argue that drugs and special diets have always been a part of the Olympics and permitting athletes to consume drugs may enhanced their knowledge of the human body and such drugs could encourage sport participation. Activists who are against allowing performance enhancing drugs squabble that if people know the athlete has deceiving, they will not really enjoy watching their performance as much. The present paper focuses on the hot theme which is revolving in the use of performance enhancing drugs in sports. It provides strong arguments against allowing performance enhancing drugs with supportive facts. It is voiced by dictators that victory at all will not be appreciated if drugs are used by athlete. Permitting drugs could also lead to casual use for those who might want to build up their muscle tone. If the public came to know that sports turn around just drugs and less athleticism, the television viewers and audience at sports contests will decrease very speedily. In such a case, spot organization has to face serious financial problems for the athletes. Drug scandals may cause the media and athletic sponsors to juggle around with their promise to that particular sport. Athletes were using drugs to enhance their performance from early times. In the games of the third Olympiad, Thomas Hicks won the marathon after receiving an injection of strychnine in the middle of the race (Seventh Report of Session 2003-2004). The first official ban on stimulating substances by a sporting organization was initiated by the International Amateur Athletic Federation in 1928. In 1976, the East German swimming team won 11 out of 13 Olympic events, and later took legal action the government for giving them anabolic steroids (New York Times 2004). The use of illegal substances is prevalent despite the health risks, and despite the regulating body’s efforts to abolish drugs from sport. Most athletes are also relatively improbable to ever undergo testing. The International Amateur Athletic Federation approximates that only 10-15% of participating athletes are tested in each main contest. Everyone recognizes that drugs are against the rules. Sport organizers must have to define the rules of sport. If the drugs are legalized and freely available, the consequences will be dangerous such health hazards and loss faith of public. People perform well at sport as a result of the genetic makeup that happened to deal them a captivating hand. The capability to perform well in sporting events is determined by the ability to deliver oxygen to muscles. Oxygen is carried by red blood cells. The more red blood cells, the more oxygen player can carry. This in turn controls an athlete’s performance in aerobic exercise. If it is raised naturally, it is well accepted. But the injection of EPO which is a natural hormone that stimulates red blood cell production, increasing the packed cell volume (PCV) the percentage of the blood comprised of red blood cells was officially banned in 1985 because it is against sports ethics (JAMA 1996; 276:231-7). Health factor involved in using EPO intravenously is that raising the PCV too high by this injection can cause serious health problems. The risk of harm quickly augments as PCV gets above 50%.

Trials of conventional criminals and terrorists Essay

Trials of conventional criminals and terrorists - Essay Example ition (in all of its senses, military or paramilitary, solutions, specialist courts or tribunals.† (Renwick & Treverton, p.1) Conventional criminals mostly commit crimes in their own country and hence the trials of such criminals are easy for the court. On the other hand in most of the cases terrorist commit crime in another country and hence their trial often poses lot of headaches to the court. Four essentials of a conventional criminal trial system are: strong and independent prosecutors; efficient and properly paid defence lawyers; ready access by defence lawyers to their clients in custody; and a modern communications system. (Review of the Criminal Courts of England and Wales) Conventional trial of a criminal often conducted in a criminal or magistrate court with the help of a judge, prosecutors, criminal advocates, witnesses etc. The judge will hear the claims of both the prosecution advocate and the criminal advocate before reaching the conclusion and declaring whether the accused committed any crime or not. In order to convince the judge the advocates (prosecution and criminal) usually presents evidences and witnesses along with the first information report (FIR) by the police who investigated the crime. The advocates will cross exam the evidences and the witnesses in order to prove their arguments. Finally the judge will reach a conclusion after hearing and evaluat ing all the arguments and evidences and will declare his verdict. Trial of a terrorist usually involves lot of complicated procedures. Quiet often special courts have been put up in order to conduct a proper and fair trial for the crime conducted by the terrorists. â€Å"In deciding whether to charge suspected terrorists, and in conducting their trials, prosecutors have difficult choices to make while maintaining proper standards of conduct. The first question, however, is how and in what context terrorists should be prosecuted.† (Renwick & Treverton, p.10) â€Å"Civilian courts do not provide

Why is ethically correct to criticize competitors through comparative Essay

Why is ethically correct to criticize competitors through comparative advertisement - Essay Example Ever since its approval, comparative advertisements has been compared to a double edged sword in which it promotes one product whereas demotes the other. An ideal comparative advertisement provides the customers with honest and sincere information in order to compete with a product so that the consumers can make a better choice while purchasing the commodity. Various researches proved that comparative advertisements help to create awareness among consumers, hence, the less popular brands become popular and the market for the popular brands tend to decrease. Comparative advertisement is considered unethical when the comparison provides the consumer with fake information and misleads the customer on purpose. Hence unethical comparative advertisements may also result in lawful proceedings. In accordance with one court any oblique remark, any indirect proclamation or any suggestions that may mean more than one thing are considered unethical. It is also considered wrong if an advertisemen t flatters their product in comparison to other. Furthermore, any sort of name calling, insulting and finger pointing are considered wrong and should be avoided at all possible costs when indulging in comparative advertisements. To keep a check and balance on comparative advertisements and to keep it within limits various organizations in the United States such as American Association of Advertising Agencies, the National Association of Broadcasters and the FTC have issued do’s and don’ts of comparative advertisements. One such example is of NBC, which says that the companies should not discredit, disparage or attack the competitors, products or industries in an unfair way (BoveÃŒ e & Arens, 1982). A list of guidelines by The American Association of Advertising Agencies is made up of ten points which ensures that a comparative advertisement remains within the ethical boundaries. The first point